Improving Surface Imprinting Effect by Reducing Nonspecific Adsorption on Non-Imprinted Polymer Films for 2,4-D Herbicide Sensors

Surface imprinting used for template recognition in nanocavities can be controlled and improved by surface morphological changes. Generally, the lithographic technique is patterning concerning sensing signal amplification molecularly imprinted polymer (MIP) thin films. In this paper, we describe effects of silanized silica molds on properties MIP Porous poly(MAA–co–EGDMA) films were lithographically fabricated using or non-treated normal replica to detect 2,4-dichlorophenoxyacetic acid (2,4-D) herbicide as standard template. The mold film (st-MIP) (?f = ?1021 Hz) exhibited a better response than (n-MIP) ?978 because effects, which occurred via functional groups surface, could reduced through silane modification. Particularly, two non-imprinted (NIP) (st-NIP n-NIP) significantly different responses. st-NIP (?fst-NIP ?332 lower ?f values n-NIP (?fn-NIP ?610 owing remarkably functionality against nonspecific adsorption. This phenomenon led factor (IF) (IFst-MIP 3.38 IFn-MIP 1.86), was calculated from adsorbed 2,4-D mass per unit weight (i.e., QMIP/QNIP). Moreover, it found that st-MIP had selectivity n-MIP based analogous solutions. As result, revealed patterned molds’ chemical modification, controls during photopolymerization, plays role fabricating enhanced